Association between hormone replacement therapy and clinical outcomes in women with rotator cuff tears.

Andrew J Nasr, Wenting Liu, Folefac Atem, Rashmi Pathak, Michael Khazzam, Nitin B Jain

Abstract read

In one paragraph

Article in Archives of ISPRM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew J NasrSchool of Physical Therapy, Texas Woman's University, Dallas, TX, USA.

Wenting LiuDepartment of Biostatistics and Data Science, University of Texas Health Science Center, Houston, TX, USA.

Folefac AtemDepartment of Biostatistics and Data Science, University of Texas Health Science Center, Houston, TX, USA.

Rashmi PathakDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Michael KhazzamBaylor Scott & White, Orthopaedic Associates of Dallas, Complex Shoulder Institute, Grapevine, TX, USA.

Nitin B JainDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Funding

The Genetic Epidemiology of Rotator Cuff Tears: the cuffGEN Study - SupplementR01AR074989 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAIN, NITIN B · 2020 to 2025

$3.6M

NIAMS NIH HHS R01 AR074989

6 · The paper itself

Abstract

Objectives: This study aims to evaluate the association between hormone replacement therapy (HRT) use and clinical outcomes in women with rotator cuff tears (RCTs) over a five-year follow-up period. Patients and methods: Between February 2011 and June 2015, a total of 77 women aged ≥ 45 years with symptomatic RCTs in a multi-center cohort were retrospectively analyzed. The HRT status was self-reported. Patient-reported outcome measures included the American Shoulder and Elbow Surgeons (ASES) score, Shoulder Pain and Disability Index (SPADI), and Mental Health Inventory (MHI), assessed at multiple time points over 60 months. Magnetic resonance imaging data were used to evaluate tear size, muscle atrophy, and fatty infiltration. Results: Of a total of 77 women included in the analysis, the HRT group consisted of 13 patients and the non-HRT group consisted of 64 patients. The mean age of women receiving HRT was 58.7 ± 7.0 years, compared to 63.5 ± 8.6 years in those not on HRT ( Conclusion: Hormone replacement therapy use demonstrated distinct functional recovery trends in women with rotator cuff tears, particularly among non-operatively managed patients, though no statistically significant differences in overall clinical outcomes were observed. These findings suggest that hormonal status may selectively influence musculoskeletal recovery and warrant further investigation to better inform sex-specific management for rotator cuff tears during and following the menopause transition.

Indexed as

Clinical outcomesrotator cuff repairrotator cuff tearsex hormonesshoulder arthroscopy

Identifiers

PMID42500023

PMCPMC13398820

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.