Evidence map›Paper›PMID 42499734›Full record

ArticleJPGN reports2026

Transnasal endoscopy for eosinophilic esophagitis surveillance in adolescents with mild autism spectrum disorder: A single-center case series.

Natalee Sarintra, Robbie Pesek, Travis Ayers, Christina Tootle, Sulaiman S Bharwani, Alejandro Ramirez, Hamza Hassan Khan

Abstract read
In one paragraph

Article in JPGN reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalee SarintraDepartment of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.ORCID https://orcid.org/0009-0008-8446-7076
Robbie PesekDivision of Allergy and Immunology, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Travis AyersDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Christina TootleDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Sulaiman S BharwaniDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Alejandro RamirezDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Hamza Hassan KhanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Arkansas Children's Hospital University of Arkansas for Medical Sciences Little Rock Arkansas USA.ORCID https://orcid.org/0000-0001-7024-974X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with autism spectrum disorder (ASD) often experience sensory sensitivities and procedural anxiety, which can complicate sedated esophagogastroduodenoscopy (EGD). Transnasal endoscopy (TNE) is a less invasive, unsedated alternative, but data on its use in this population are limited. We evaluated the safety, tolerability, and clinical utility of sedation-free TNE in adolescents with Level 1 ASD (mild autism) undergoing surveillance for eosinophilic esophagitis (EoE). In this retrospective case series, five adolescents (mean age 13.2 years; 80% male) underwent TNE between April 2024 and April 2025. We assessed procedural success, adverse events, biopsy adequacy, and behavioral strategies. All procedures were completed successfully without sedation or serious adverse events. Child Life Specialists (CLSs) supported 80% of cases, using behavioral aids, such as virtual reality (VR) goggles and desensitization tools. Mean procedure time was 10.75 ± 1.96 min. We concluded that TNE is a safe and feasible alternative to sedated EGD in carefully selected adolescents with mild ASD and warrants further study in larger cohorts.

Indexed as

dysphagiaesophageal biopsyesophageal inflammationneurodivergentsedation‐free mucosal evaluation

Identifiers

PMID42499734
PMCPMC13398690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.