ArticleFrontiers in microbiology2026
Tumour tissue-associated microbiome differences between colonic adenoma and carcinoma revealed by 5R 16S rRNA sequencing of formalin-fixed paraffin-embedded tissues: a case-control study.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tumour-associated microbiota directly colonise lesion sites and interact with the local immune microenvironment, yet their compositional shifts during the adenoma-to-cancer transition remain poorly characterised, particularly in archival tissue. Using five-region 16S ribosomal RNA (5R 16S rRNA) sequencing with a four-category contamination control framework, we compared tumour-associated microbiomes in formalin-fixed paraffin-embedded (FFPE) tissues from 25 colonic tubular adenoma and 25 colon cancer patients in a case-control design. Alpha diversity was significantly reduced in the colon cancer group across three indices (Shannon, Simpson, and Pielou's evenness), reflecting shifts in community evenness rather than overall species loss. Beta diversity analysis, however, revealed no significant differences in global community composition between groups (ANOSIM:
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