ArticleDepression and anxiety2026
Latent Symptom Profiles in Adolescents With Major Depressive Disorder: Subjective Sleep Disturbance and Biopsychosocial Correlates.
Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Latent Symptom Profiles in Adolescents With Major Depressive Disorder: Subjective Sleep Disturbance and Biopsychosocial Correlates.Depression and anxiety · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Adolescent major depressive disorder (MDD) is clinically heterogeneous, with sleep disturbance often emerging as a prominent but variably expressed symptom dimension. This study aimed to identify latent symptom profiles in drug-naïve adolescents with MDD and examine their associations with recorded trauma/stressor exposure and neuroendocrine markers. Methods: This cross-sectional study included 711 drug-naïve adolescents with MDD. Latent profile analysis (LPA) was conducted using 16 symptom indicators derived from the Hamilton depression rating scale (HDRS), Hamilton anxiety rating scale (HAMA), and Pittsburgh sleep quality index (PSQI). Multinomial logistic regression examined associations of recorded trauma/stressor exposure and neuroendocrine markers with profile membership. Results: A three-profile solution was retained: low overall symptoms (Profile 1; Conclusion: LPA identified three clinically interpretable symptom profiles in adolescent MDD, including a profile characterized primarily by elevated PSQI-assessed subjective sleep disturbance. Recorded trauma/stressor exposure was associated with the high overall symptom profile, whereas neuroendocrine markers showed limited incremental value. These findings highlight multidimensional symptom profiling and trauma assessment in adolescent depression, while suggesting that neuroendocrine findings should be considered exploratory.
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