Stereodivergent total synthesis of C5/C6-oxygenated angucyclines: stereochemical reassignment and antitumor activities.

Yuting Cheng, Zihao Dai, Peng Xu, Yingjie Wang, Biao Yu

Abstract read

In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuting ChengDepartment of Chemistry, University of Science and Technology of China Hefei 230026 P. R. China.

Zihao DaiState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China wangyj@sioc.ac.cn byu@sioc.ac.cn.

Peng XuState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China wangyj@sioc.ac.cn byu@sioc.ac.cn.ORCID https://orcid.org/0000-0002-9593-7167

Yingjie WangState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China wangyj@sioc.ac.cn byu@sioc.ac.cn.ORCID https://orcid.org/0000-0002-6642-8726

Biao YuState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China wangyj@sioc.ac.cn byu@sioc.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A unified total synthesis of 16 stereochemically defined 5,6-diol-bearing tetrangomycin-type angucyclines, including PD-116740, TAN-1085, himalaquinone G, and their congeners, was achieved. The synthesis features an acid-catalyzed hydration and subsequent retro-Friedel-Crafts-type ring-opening of a strained cyclobutene precursor to rapidly elaborate the angucycline framework. A completely catalyst-controlled reduction

Identifiers

PMID42499571

DOI10.1039/d6sc04876e

PMCPMC13398419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.