Evidence map›Paper›PMID 42499566›Full record

ArticleFrontiers in pediatrics2026

Clinical characteristics and cytokine profiles for early prediction of severe

Jiayi Xue, Tao Ai, Yinghong Fan, Cheng Xie, Wanmin Xia, Li Wang

Abstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiayi XueDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Tao AiDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yinghong FanDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Cheng XieDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wanmin XiaDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Li WangDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To investigate the clinical characteristics and cytokine profiles of children with Methods: This prospective study enrolled 445 children with MPP admitted to the Department of Pediatric Respiratory Medicine of Chengdu Women's and Children's Central Hospital between December 2022 and December 2023. Based on disease severity, patients were assigned to the mild MPP (MMPP, Results: Among the 445 children, 255 cases (57.3%) developed SMPP. Multivariate regression analysis showed that wheezing (OR=4.016, 95% CI: 1.609-10.029), shortness of breath (OR=4.717, 95% CI: 1.290-16.008), D-dimer (OR=3.032, 95% CI: 1.926-4.773), CRP (OR=1.033, 95% CI: 1.018-1.048), fever (OR=3.432, 95% CI: 1.658-7.105), and age (OR=1.114, 95% CI: 1.015-1.223) were independent risk factors for SMPP (all Conclusion: A predictive nomogram incorporating wheezing, shortness of breath, fever, D-dimer, CRP, and age was established for early risk stratification of SMPP in hospitalized children. Multiple serum cytokines were significantly elevated in SMPP patients, and their potential clinical utility warrants further investigation in larger cohorts.

Indexed as

childcytokinesMycoplasma pneumoniaenomogrampneumoniaprediction model

Identifiers

PMID42499566
PMCPMC13395776

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.