Cutaneous biodistribution of topically applied active ingredients: Evaluation of intra- and inter-laboratory reproducibility.

Si Gou, Anne Moustie, Kevin Caché, Luca Insolia, Jun Wu, Sébastien Grégoire, Stéphane Guerrier, Yogeshvar N Kalia

Abstract read

In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Pharmacokinetic Relevance of In Vitro Skin Models: Absorption, Cutaneous Distribution, Metabolism, and Clearance-like Removal in Dermal and Transdermal Drug Testing.Pharmaceutics · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Si GouSchool of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.

Anne MoustieL'Oréal R&I France, 1 Av. Eugène Schueller, 93600 Aulnay-Sous-Bois, France.

Kevin CachéL'Oréal R&I France, 1 Av. Eugène Schueller, 93600 Aulnay-Sous-Bois, France.

Luca InsoliaSchool of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.

Jun WuGeneva School of Economics and Management, University of Geneva, 1211 Geneva, Switzerland.

Sébastien GrégoireL'Oréal R&I France, 1 Av. Eugène Schueller, 93600 Aulnay-Sous-Bois, France.

Stéphane GuerrierSchool of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.

Yogeshvar N KaliaSchool of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A robust method to quantify the spatial distribution of active ingredients and their concentrations as a function of depth within the epidermis and dermis would be advantageous for both cosmetic and pharmaceutical products. Here, a cassette-based in vitro permeation test (IVPT) was performed (at a given site) under finite dose conditions with five physicochemically distinct substances (with a > 350,000-fold difference in lipophilicity) using human abdominal skin - both permeation and total deposition were determined. A total of eighteen skin discs (area = 2 cm

Indexed as

Cutaneous biodistribution methodInter-laboratoryIntra-laboratoryMathematical modelTopically applied active ingredientsValidation

Identifiers

PMID42499561

DOI10.1016/j.ijpx.2026.100618

PMCPMC13396900

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.