ArticleFrontiers in aging neuroscience2026
Relationship between executive function and activities of daily living in Alzheimer's disease: a study based on the stop-signal task.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Early clinical manifestations of Alzheimer's disease (AD) include an apparent decline in memory and executive function. Executive function is closely related to activities of daily living (ADL) and is important for maintaining an independent, high-quality lifestyle. Objective: This study aimed to explore the executive control ability and neuromechanisms of AD patients through stop-signal task (SST) elicited event-related potentials (ERPs) and their relationship with ADL. Methods: Thirty-six patients with AD and 36 sex and age matched healthy controls (HCs) were recruited. Electroencephalography (EEG) data recorded during the SST was compared between groups, and SST-related indicators were determined to assess executive control ability in AD patients. The relationship between ADL and SST-related indicators was explored. We performed Receiver Operating Characteristic (ROC) analysis on SST- and EEG-related indices. Results: Differences in the following indices were found between the two groups: Go accuracy ( Conclusion: This study suggests that the worse the executive function of AD patients, the more serious the ADL impairment. AD patients have electrical abnormalities associated with executive control. Different SST- and EEG-related indicators can be used to diagnose AD. This provides a new avenue for further elucidation of the pathological mechanisms of AD.
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