Evidence map›Paper›PMID 42499455›Full record

ArticleKidney medicine2026

Thyroid Stimulating Hormone Levels and Risk of Hospital-Acquired Acute Kidney Injury: A Nationwide Cohort Study.

Caoxiang She, Yaduan Lin, Yanan Xie, Shiyu Zhou, Fan Luo, Ruixuan Chen, Luhua Jin, Lantian Li, Linjiang Chen, Xian Shao and 1 more

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Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Caoxiang SheDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Yaduan LinDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Yanan XieDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Shiyu ZhouDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Fan LuoDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Ruixuan ChenDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Luhua JinDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Lantian LiDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Linjiang ChenDepartment of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xian ShaoDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Sheng NieDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Multiorgan Injury Prevention and Treatment, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale & Objective: The thyroid-renal interaction remains underexplored in acute kidney injury pathophysiology. We aimed to investigate the relationship between thyroid status, defined by thyroid-stimulating hormone (TSH) levels, and incident hospital-acquired acute kidney injury (HA-AKI). Study Design: A retrospective cohort study. Setting & Participants: Patients with TSH quantification within 48 hours after admission from the China Renal Data System (CRDS) database. Exposures: Three TSH levels groups, including hyperthyroid (TSH ≤ 0.5 mIU/L), euthyroid (0.5 < TSH ≤ 5.0 mIU/L), and hypothyroid (TSH > 5.0 mIU/L) TSH levels. Outcomes: The primary outcome was HA-AKI. Analytical Approach: Multivariable Cox hazard regression models and restricted cubic spline. Results: A total of 20,317 (5.4%) patients developed HA-AKI, with incidences rates of 8.0%, 5.0%, and 6.4% in patients with hyperthyroid, euthyroid, and hypothyroid TSH levels, respectively. Compared with patients with euthyroid TSH levels, those with hyperthyroid or hypothyroid TSH levels were associated with an increased risk of HA-AKI (hyperthyroid TSH levels: adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.21-1.37; Limitations: Possible residual confounding. Conclusions: TSH levels in the low (≤0.5 mIU/L) and high (>5.0 mIU/L) ranges were associated with increased risk of HA-AKI. These insights suggest that enhanced vigilance toward AKI may be justifiable in patients with thyroid dysfunction.

Indexed as

Hospital-acquired acute kidney injuryreal-world evidencethyroid hormonesthyroid–renal crosstalkthyroid-stimulating hormone

Identifiers

PMID42499455
PMCPMC13396862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.