Associations of Nephron Number, Birth Weight, and Causes of Death in a Community at High Risk of Hypertension and Cardiovascular Disease.

Michael D Hughson, Rebecca N Douglas-Denton, Wendy E Hoy, Cheryl A Winkler, Jeffrey B Kopp, John F Bertram

Abstract read

In one paragraph

Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Michael D HughsonUniversity of Mississippi Medical Center, Jackson, MI.

Rebecca N Douglas-DentonDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Wendy E HoyCentre for Chronic Disease, The University of Queensland, Brisbane, Queensland, Australia.

Cheryl A WinklerBasic Research Laboratory, Center for Cancer Research, National Institutes of Health, Leidos Biomedical Inc., Frederick National Laboratory, Frederick, MD.

Jeffrey B KoppKidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD.

John F BertramDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Funding

Nephron Count, Birth Weight &Hypertensive Renal DiseaseR01DK065970 · NIDDK · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HUGHSON, MICHAEL DONALD · 2004 to 2006

$659k

NIDDK NIH HHS R01 DK065970

6 · The paper itself

Abstract

Rationale & Objective: Low birth weight (LBW) and low nephron number may increase the risk of hypertension and cardiovascular disease (CVD). Study Design: Total glomerular number was determined by stereological analysis of autopsy kidneys from 336 participants. Health Department-recorded birth weights were obtained for 204 participants who were ≤55 years old. Outcomes: Birth weight, nephron number. Predictors: Hypertension, CVD, age, biological sex, body mass index, poverty index, and Analytical Approach: Relationships were investigated using group comparisons and regression models. Settings & Participants: Performance sites: Autopsies, University Medical Center, Jackson, MS; Stereology, Department of Anatomy and Developmental Biology, Monash University, Melbourne; Results: In total, 170 participants having birth weights were adults, 29% of adults were hypertensive, and 40% died of CVD. Genotyping identified 22 Black participants with 2 Limitations: Relationships of predictors to outcomes are abridged by death at recruitment. Conclusions: LBW and low nephron number were not related to hypertension or CVD in adults ≤ 55 years of age, but a glomerulosclerosis-related reduction in glomerular number may contribute to hypertension and CVD in later life.

Indexed as

birth weightcardiovascular diseasehypertensionNephron number

Identifiers

PMID42499453

DOI10.1016/j.xkme.2026.101432

PMCPMC13396860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.