ArticleTurkish journal of medical sciences2026
Impact of race-based and race-free CKD-EPI equations on estimated glomerular filtration rate in a multicenter retrospective cohort of autosomal dominant polycystic kidney disease.
Article in Turkish journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aim: The 2021 revision of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, which eliminates race-based coefficients, may significantly influence disease staging and treatment in autosomal dominant polycystic kidney disease (ADPKD). This study was designed to evaluate the impact of the 2021 race-free CKD-EPI equation on estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) staging in a multi-ethnic ADPKD population. Materials and methods: In this multicenter, retrospective cohort study, 597 ADPKD patients were evaluated, including 515 self-identified as Caucasian and 82 as African-American. eGFR values at baseline and final follow-up were calculated using both the 2009 and 2021 CKD-EPI equations. Changes in CKD staging and clinical implications were assessed based on the race-free equation. Results: Among Caucasian patients, the median baseline eGFR increased from 85.0 to 88.6 mL/min/1.73 m Conclusion: The 2021 CKD-EPI equation significantly alters eGFR estimation and CKD staging compared to the 2009 version, with varying impacts across ethnic groups. These findings highlight the importance of careful interpretation of eGFR and individualized clinical decision-making in patients with ADPKD.
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