ReviewCureus2026
Pooled Oncological Outcomes in Marjolin's Ulcer: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Radiotherapy for postoperative groin lymphatic fistulas: A systematic review of clinical outcomes and treatment planning.Clinical and translational radiation oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marjolin's ulcer is a rare, aggressive cutaneous malignancy arising in chronic wounds, scars, and burns, for which prognostic and treatment data remain fragmented across small retrospective series. We conducted a systematic review and meta-analysis, registered with the International Prospective Register of Systematic Reviews (PROSPERO) and performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), searching PubMed, EMBASE, Scopus, the Cochrane Library, and ScienceDirect for case series and cohort studies (≥10 patients) reporting histologically confirmed malignancy arising in scars, ulcers, or chronic wounds. Pooled proportions were estimated using random-effects models (restricted maximum likelihood (REML)) with logit transformation, treatment arms were compared using log risk ratios, and risk of bias was assessed with the Joanna Briggs Institute (JBI) checklist. Fifty-one studies comprising 2,388 patients across 18 countries were included. Squamous cell carcinoma predominated (95.7%), arising chiefly in the lower limb (58.9%) after a long latency (median 29.5 years). The pooled local recurrence rate was 20% (95% confidence interval (CI) 16%-24%; I² = 66.3%), while the pooled rate of regional nodal metastasis at diagnosis was 19% (95% CI 15%-24%; I² = 78.5%); the pooled five-year overall survival was 61% (95% CI 49%-72%). Adding adjuvant radiotherapy to surgery showed no significant effect on local recurrence (log risk ratio 0.78, 95% CI -1.56-3.12), though confounded by indication. Evidence certainty was low to very low; wide local excision with clear margins, according to the oncological principles, remains the cornerstone of management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.