ArticleInternational journal of dentistry2026
Inflammatory and Oxidative Stress Biomarkers in Gingival Crevicular Fluid (GCF) and Serum of Dogs With Gingivitis and Periodontitis.
Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Inflammatory and Oxidative Stress Biomarkers in Gingival Crevicular Fluid (GCF) and Serum of Dogs With Gingivitis and Periodontitis.International journal of dentistry · 2026Article
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2 authors.
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Abstract
Introduction/Objectives: Periodontal disease is one of the most common oral disorders in dogs and is characterized by inflammation and destruction of periodontal tissues. This study aimed to compare local and systemic inflammatory and oxidative stress biomarkers in dogs with gingivitis and periodontitis and to evaluate neopterin as a potential biomarker of periodontal inflammation. Materials and Methods: A total of 52 dogs were included, comprising 26 dogs with gingivitis and 26 dogs with periodontitis. Gingival crevicular fluid (GCF), blood, and serum samples were collected. Total oxidant status (TOS), total antioxidant status (TAS), caveolin-1, monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-1β, IL-6, neopterin, and selected hematological variables were measured. Biomarker concentrations and correlations between serum and GCF were evaluated. Results: Dogs with periodontitis exhibited significantly higher serum TOS, TAS, and IL-6 concentrations than dogs with gingivitis ( Conclusions: Periodontal disease in dogs was associated with distinct stage-dependent inflammatory and oxidative stress profiles. Gingivitis was characterized by increased levels of several inflammatory mediators, whereas periodontitis was associated with increased oxidative stress and IL-6 concentrations. These findings suggest that local and systemic biomarker responses vary according to periodontal disease stage and warrant further investigation of GCF biomarkers for monitoring periodontal inflammation.
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