ArticleBirth defects research2026
Effects of Nimodipine on Neural Tube Development in Early Chick Embryos.
Article in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundAlthough nimodipine is the only calcium channel blocker routinely used for the treatment of aneurysmal subarachnoid hemorrhage, its precise mechanism of action remains unknown. Therefore, this study investigated the effects of nimodipine on many cells in the body due to its effect on calcium channels and neural tube development, especially in pregnancy.
methodsA total of 100 fertile and 0-day-old specific pathogen-free (SPF) eggs of White Leghorn weighing 65 ± 5 g were used. SPF eggs were randomly divided into four groups: a control group and three different dose groups. SPF eggs were incubated for 28 h under appropriate temperature and humidity conditions. At the end of 28 h, nimodipine was subblastodermicly administered using a Hamilton microinjector at three different doses. At 48 h, all eggs were hatched, and the embryos were removed from the embryonic membranes. Then, morphological, histopathological, cell proliferation (PCNA), and genetic analyses were performed.
resultsThe results of the morphological analysis revealed that when the frequency of neural tube patency was evaluated among the experimental groups, a statistically significant difference was determined between the control group and all groups (p < 0.001). Furthermore, the mean crown-rump length and somite number of the embryos were dose-dependently lower than the control group (p < 0.001). Nimodipine exposure dose-dependently decreased the PCNA and increased the caspase-3, with this change being significant between the experimental groups.
conclusionsIn conclusion, nimodipine exposure delayed neural tube closure in chicken embryos by suppressing proliferation and apoptosis induction. Nimodipine exposure delayed neurogenesis and development in early chick embryos.
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