Evidence map›Paper›PMID 42499289›Full record

ArticleClinical transplantation2026

Cardiac Troponin I (cTnI) Dynamics After Lung Transplantation and Its Consequences for Early Postoperative Management.

Stefan Kuhnert, Janine Sommerlad, Merlin Moritz Seibert, Athiththan Yogeswaran, Martin Reichert, Ingolf Askevold, Andreas Hecker, Christian Koch, Werner Seeger, Matthias Hecker

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Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Stefan KuhnertDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Janine SommerladDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Merlin Moritz SeibertDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Athiththan YogeswaranDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Martin ReichertDepartment of General, Visceral, Thoracic and Transplant Surgery, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany.
Ingolf AskevoldDepartment of General, Visceral, Thoracic and Transplant Surgery, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany.
Andreas HeckerDepartment of General, Visceral, Thoracic and Transplant Surgery, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany.
Christian KochDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Werner SeegerDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Matthias HeckerDepartment of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial injury with elevated cardiac troponin I (cTnI) is common after cardiac or even thoracic surgery and may indicate impaired prognosis. While cTnI has been monitored after lung transplantation routinely (LuTX), its relevance is to be elucidated. Therefore, this study focused on cTnI dynamics and its prognostic value after LuTX.

methodsThis retrospective study analyzed data from 151 adult patients who underwent a LuTX at a single German lung center between 2005 and 2022. It focused on cTnI levels and dynamics at four postoperative time points, their impact on LuTX outcomes, and possible risk factors for elevated cTnI.

resultsElevated cTnI above the upper limit of normal was a regular finding early after LuTX without independent prognostic value, peaking 5-8 h postoperative. However, a failure to subsequently decrease may indicate a higher risk of mortality. Patients' cTnI levels showed weak positive correlations with duration of mechanical ventilation and length of stay in the intensive care unit. DISCUSSION: Elevated cTnI levels after LuTX might impact patient outcomes. However, larger multi-center studies are needed to conclusively determine their impact.

Indexed as

BiomarkersLung TransplantationPostoperative CarePostoperative ComplicationsTroponin IAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative PeriodPrognosisRetrospective StudiesRisk FactorsSurvival RateBiomarkersTroponin Iadult patientscardiothoracic surgeryintensive care unitinternal medicinelung transplantationmechanical ventilationmedicineretrospective cohort studytroponintroponin i

Identifiers

PMID42499289
PMCPMC13401093

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