Evidence map›Paper›PMID 42499264›Full record

Observational studyPediatric blood & cancer2026

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross-Sectional Study.

Hari K Narayan, Sitong Chen, F Lennie Wong, Nathan Young, Anna Qi, Christopher Davis, Sanjeet Hegde, Nicholas Gloude, Kasey J Leger, Kelly D Getz and 6 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric blood & cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04262830 (CATCH-HF), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04262830 recruitingnot on this map

CATCH-HF: Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

TypeobservationalSponsorHari NarayanRan2019 to 2030Enrolled150ConditionsCardiotoxicity, Pediatric Cancer, Heart FailureArmsCardiac magnetic resonance imaging (MRI), Accelerometer physical activity monitoring
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hari K NarayanDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Sitong ChenDepartment of Population Sciences, City of Hope, Duarte, California, USA.
F Lennie WongDepartment of Population Sciences, City of Hope, Duarte, California, USA.
Nathan YoungDepartment of Pediatrics, Rady Children's Hospital San Diego, San Diego, California, USA.
Anna QiDepartment of Biomedical Engineering, University of California, San Diego, La Jolla, California, USA.
Christopher DavisDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Sanjeet HegdeDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Nicholas GloudeDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Kasey J LegerDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Kelly D GetzDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Francisco ContijochDepartment of Biomedical Engineering, University of California, San Diego, La Jolla, California, USA.
Kirsten NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Bonnie KyDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dennis KuoDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Sheri J HartmanHerbert Wertheim School of Public Health, University of California, San Diego, La Jolla, California, USA.
Saro H ArmenianDepartment of Population Sciences, City of Hope, Duarte, California, USA.

Funding

The Clinical Relevance of Anthracycline-Related Cardiac Remodeling in Childhood Cancer SurvivorsK23HL163456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hari Kope Narayan · 2023 to 2026
$786k
NHLBI NIH HHS K23 HL163456NHLBI NIH HHS K23HL163456St. Baldrick's Foundation
6 · The paper itself

Abstract

introductionAnthracycline-related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient-specific factors, moderate-to-vigorous physical activity (MVPA), and cardiac remodeling.

methodsWe performed a prospective, observational, cross-sectional study in ≥ 2-year survivors treated with anthracyclines. We derived MVPA from accelerometry and cardiac parameters (indexed end-diastolic left ventricular [LV] mass [LVMi], volume [LVEDVi], mass:volume ratio, and LV ejection fraction [LVEF]) from cardiovascular magnetic resonance imaging. We assessed predictors of MVPA and the association between MVPA and cardiac parameters using multivariable linear regression.

resultsAmong 112 participants, mean age was 18.2 years (standard deviation [SD] 3.0) and mean anthracycline dose was 239 mg/m

conclusionPhysical activity levels were suboptimal and higher levels of MVPA were associated with higher LV mass and volume. Our findings suggest the need to promote physical activity in childhood cancer survivors and that exercise may mitigate anthracycline-related cardiac remodeling. TRIALS REGISTRATION: ClinicalTrials.gov identifiers: NCT04262830.

Indexed as

AnthracyclinesCancer SurvivorsExerciseNeoplasmsVentricular RemodelingAdolescentAdultChildCross-Sectional StudiesFemaleFollow-Up StudiesHumansMalePrognosisProspective StudiesYoung AdultAnthracyclinescancer therapy related cardiac dysfunctioncardiac remodelingcardiotoxicitychildhood cancer survivorspediatric cardio‐oncologyphysical activity

Identifiers

PMID42499264
PMCPMC13657381

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.