Evidence map›Paper›PMID 42498976›Full record

Observational studyCancer medicine2026

Longitudinal Associations Between Inflammatory Biomarkers and Fatigue in Patients With Colorectal Cancer: A Multicenter Study.

Nicole C Loroña, Louisa Liu, Elham Kazemian, Nicholas Acuna, Mary C Playdon, Christopher L Cubitt, Shaowli Kabir, Sylvia L Crowder, Nathalie Nguyen, Maria Gomez and 21 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Nicole C LoroñaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8302-3157
Louisa LiuDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Elham KazemianSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.
Nicholas AcunaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.
Mary C PlaydonHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Christopher L CubittImmune Monitoring Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Shaowli KabirSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5839-2460
Sylvia L CrowderDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Nathalie NguyenSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.
Maria GomezDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Victoria DamerellDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Kathi MooneyCollege of Nursing and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Patricia A EricksonHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Mmadili IlozumbaHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Caroline HimbertHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Erin SiegelDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Cornelia M UlrichHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
David ShibataDepartment of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Adetunji T ToriolaDepartment of Surgery, Division of Public Health Sciences, and Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Jennifer OseHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-2030-9676
Anita R PeoplesHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Sheetal HardikarHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
Doratha A ByrdDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Julienne E BowerDepartment of Psychology, University of California Los Angeles, California, Los Angeles, USA.
Aasha I HooglandDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Xiaoyin LiDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-8028-8910
Brent J SmallSchool of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-7444-4689
Biljana GigicDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Heather S L JimDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-7353-3711
Jane C FigueiredoSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Cancer, Los Angeles, California, USA.

Funding

Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6M
Novel Biomarkers for Cancer-Related Fatigue: Integrating Metabolomics, Genomics and BehaviorsR01NR018762 · NINR · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., JIM, HEATHER S.L. · 2020 to 2024
$3.4M
NCI NIH HHS U01 CA206110NCI NIH HHS U01CA206110NINR NIH HHS R01 NR018762NINR NIH HHS R01NR018762
6 · The paper itself

Abstract

purposeFatigue affects up to 90% of patients with cancer during chemotherapy and persists in approximately 30% after treatment completion. This study examined the longitudinal associations between fatigue and 16 inflammatory markers in patients with colorectal cancer (CRC) up to 3 years after surgery.

methodsPatients with Stage I-IV CRC who participated in the prospective ColoCare cohort study were included. Fatigue was measured using the 3-item fatigue subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) at baseline and each subsequent time point (score range: 0-100). Inflammatory markers were measured using blood specimens from each time point (T0: baseline/surgery; T1: 3-9 months; T2: 10-19 months; T3: 20-36 months post-baseline). Linear mixed-effects models were used to examine associations between inflammatory markers and fatigue scores over time. Linear regression was used to analyze the relationships between T0/T1 markers and fatigue at T3.

resultsThere were 271 patients with Stage I-III CRC and 30 patients with Stage IV CRC. Among patients with Stage I-III CRC, mean fatigue peaked at T1 (36.9), with higher fatigue among women than men (44.8 vs. 30.9). In longitudinal mixed-effects models, twofold higher mean levels of IL-6 and IL-17A were associated with higher fatigue over time (3.51 (p = 0.01) and 3.91 (p = 0.01), respectively). IL-4, IL-17A, and TNF-α at T1 were nominally associated with higher levels of fatigue at T3.

conclusionHigher levels of selected inflammatory biomarkers were associated with fatigue up to 3 years after CRC diagnosis. These markers may help identify patients at risk for persistent fatigue and warrant further study as potential therapeutic targets.

Indexed as

Biomarkers, TumorColorectal NeoplasmsFatigueInflammationAgedBiomarkersCytokinesFemaleHumansLongitudinal StudiesMaleMiddle AgedNeoplasm StagingProspective StudiesQuality of LifeBiomarkersBiomarkers, TumorCytokinescolorectal cancercytokinesfatigueinflammation

Identifiers

PMID42498976
PMCPMC13400709

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.