Evidence map›Paper›PMID 42498887›Full record

ArticleDigestive diseases and sciences2026

A Practical Endoscopic Treatment Strategy for Appendiceal Orifice Lesions Using Forceps-Assisted Polypectomy (Strip Biopsy).

Toshifumi Iida, Jun Arimoto, Ai Hirohata, Akimichi Hayashi, Yu Ebisawa, Michiko Nakaoka, Tetsuo Nemoto, Hideyuki Chiba

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Toshifumi IidaDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Jun ArimotoDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Ai HirohataDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Akimichi HayashiDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Yu EbisawaDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Michiko NakaokaDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan.
Tetsuo NemotoDepartment of Pathology, Omori Red Cross Hospital, Tokyo, Japan.
Hideyuki ChibaDepartment of Gastroenterology, Omori Red Cross Hospital, 4-30-1 Chuo, Ota-ku, Tokyo, 143-8527, Japan. hchiba04@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEndoscopic treatment of small lesions involving the appendiceal orifice remains technically challenging. Although endoscopic submucosal dissection (ESD) enables en bloc resection, it may represent overtreatment for such lesions. In contrast, forceps-assisted polypectomy; strip biopsy may serve as an effective therapeutic option. The aim of this study was to propose a practical, real-world treatment strategy and to evaluate the clinical usefulness of strip biopsy.

methodsThis retrospective single-center study included patients who underwent endoscopic treatment for appendiceal orifice lesions between May 2017 and September 2025. Patients were classified into strip biopsy or ESD group. Procedural outcomes and adverse events were compared.

resultsTwenty-two appendiceal orifice lesions were included, with 14 treated by strip biopsy and 8 by ESD. Baseline characteristics were comparable. Procedure time was significantly shorter in the strip biopsy group (6.6 ± 2.9 vs. 45.9 ± 31.3 min, p < 0.05). En bloc resection rates were 93 and 100%, respectively. No perforation occurred, and delayed bleeding was observed in one ESD case only. Positive or unclear horizontal margins were more frequent in the strip biopsy group than in the ESD group (50 vs. 13%, p = 0.16). Among patients who completed 1-year surveillance colonoscopy, no local recurrence was observed.

conclusionStrip biopsy may be a feasible and rapid treatment option for carefully selected small appendiceal orifice lesions without endoscopic features suggestive of malignancy. However, because of the retrospective design, small sample size, and limited follow-up data, further prospective studies with larger cohorts and longer follow-up are warranted.

Indexed as

Appendiceal NeoplasmsAppendixColonoscopyEndoscopic Mucosal ResectionAgedBiopsyFemaleHumansMaleMiddle AgedRetrospective StudiesSurgical InstrumentsTreatment OutcomeAppendiceal orifice lesionColorectal neoplasmsEndoscopic mucosal resectionEndoscopic submucosal dissectionStrip biopsy

Identifiers

PMID42498887

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