ArticleJournal of the Association for Research in Otolaryngology : JARO2026
A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeSimultaneous hearing and balance restoration through combined cochlear-vestibular implants (CVIs) offers a promising treatment for patients with dual sensory deficits. However, the effects of electrical stimulation on neighboring neural structures in the inner ear remain poorly understood.
methodsIn this study, we present a detailed computational model of the human inner ear that simulates electrical stimulation of cochlear and vestibular nerves under clinically relevant conditions. The model integrates high-resolution micro-CT-based geometry, anisotropic tissue conductivities, and myelinated fiber models to predict neural activation patterns across a wide range of clinically relevant stimulation parameters.
resultsSimulation results suggest that vestibular stimulation at clinically relevant amplitudes can influence cochlear nerve activation thresholds, particularly in basal cochlear regions. Conversely, cochlear stimulation had a comparatively weaker effect on vestibular activation. Interleaved stimulation with short interstimulus intervals (smaller 100
conclusionThis model allows for comprehensive evaluation of scenarios that cannot be tested in humans due to ethical, practical, or technical limitations. As a result, it provides a valuable tool for exploring new combined simulation scenarios and may aid the development of newly designed implants.
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