ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026
Effects of copper overload on mitochondrial parameters in GBM-1, U-87 MG, and C6 glioma cell lines.
Giovanna Tassinari, Lorena Aparecida de Souza, Nikole Aguiar de Souza, Yasmin Radowitz Mendonça, Lara Stoeberl, Madson Silveira de Melo, Evelise Maria Nazari, Carla Inês Tasca, Cláudia Beatriz Nedel, Viviane Glaser
Abstract read
In one paragraphArticle in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Giovanna TassinariLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil.ORCID http://orcid.org/0009-0005-9954-7800 Lorena Aparecida de SouzaLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil.
Nikole Aguiar de SouzaLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil.
Yasmin Radowitz MendonçaLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil.
Lara StoeberlLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil.ORCID http://orcid.org/0000-0002-3422-3531 Madson Silveira de MeloLaboratório de Reprodução e Desenvolvimento Animal, Centro de Ciências Biológicas, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0001-5174-7348 Evelise Maria NazariLaboratório de Reprodução e Desenvolvimento Animal, Centro de Ciências Biológicas, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0002-3635-0526 Carla Inês TascaLaboratório de Neuroquímica 4, Centro de Ciências Biológicas, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0002-3414-6150 Cláudia Beatriz NedelLaboratório de Biologia Celular de Gliomas, Centro de Ciências Biológicas, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.ORCID http://orcid.org/0000-0002-9075-8127 Viviane GlaserLaboratório de Biologia Celular, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas, Universidade Federal de Santa Catarina, Campus de Curitibanos, Curitibanos, SC, Brazil. v.glaser@ufsc.br.ORCID https://orcid.org/0000-0002-3594-4314 Funding
Fundação de Amparo à Pesquisa e Inovação de Santa Catarina - FAPESC Edital 09/2024 - TR001594Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina Edital 09/2024 - TR001594
6 · The paper itselfAbstract
Over the years, there has been growing interest in developing new therapies for glioblastoma, and copper compounds have emerged as promising therapeutic targets due to their antitumoral properties. In this context, this study aimed to investigate the effects of high copper levels on cell viability, mitochondrial physiology, PINK1 content, and the expression of PGC-1α and TFAM in distinct glioma cell lines, mainly considering the heterogeneity of tumoral cells. GBM-1, U-87 MG, and C6 cells CuSO
Indexed as
CopperGliomaMitochondriaAnimalsCell Line, TumorCell SurvivalDNA-Binding ProteinsDose-Response Relationship, DrugHumansMembrane Potential, MitochondrialMitochondrial ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesPTEN-Induced Putative KinaseRatsTranscription FactorsCopperDNA-Binding ProteinsMitochondrial ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanProtein KinasesPTEN-Induced Putative KinaseTFAM protein, humanTranscription FactorsMetalsMitochondriaPGC-1αPINK1TFAM
Identifiers
PMID42498833
PMCPMC13518506
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