SynthesisPediatric research2026
Meta-analysis of nasal interfaces versus face mask during respiratory support at birth in less than 37 weeks' gestation infants.
Synthesis in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 10% of neonates require respiratory support at birth. Face mask is most commonly used during positive pressure ventilation, but the nasal interface may offer a more effective alternative. We conducted an updated meta-analysis to compare the effect of using a nasal interface versus face mask on mortality in preterm infants (<37 weeks' gestation) requiring respiratory support at birth.
methodsWe systematically searched PubMed, EMBASE, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials from inception to November 2025 for randomized controlled trials (RCTs) comparing nasal interface and face mask during delivery room (DR) stabilization of infants <37 weeks' gestation. The primary outcome measure was neonatal death (<28 days) before hospital discharge.
resultsSeven RCTs including 1270 infants were analyzed. There was no significant difference in neonatal death between nasal interface and face mask (RR 0.84, 95% CI 0.57-1.23; P = 0.37, I² = 0%). However, nasal interface significantly reduced DR intubations compared with face mask (RR 0.68, 95% CI 0.51-0.90; P = 0.007, I² = 32%).
conclusionsIn preterm infants <37 weeks' gestation, the choice of interface did not affect neonatal mortality, but the use of a nasal interface was associated with fewer DR intubations. IMPACT: Nasal interfaces significantly reduce delivery room intubation in preterm infants without increasing mortality or major neonatal morbidities compared with face mask ventilation. Using a nasal interface compared during respiratory support at birth may be associated with a potentially clinically meaningful reduction in delivery room intubation, with a preserved safety profile. Adoption of nasal interfaces during delivery room stabilization may decrease early delivery room intubation. Reducing early intubation may support smoother cardiopulmonary transition and minimize procedure-related instability in vulnerable preterm infants. These findings provide evidence to inform practice recommendations and justify larger implementation studies evaluating long-term respiratory and neurodevelopmental outcomes.
Identifiers
42498826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.