Evidence map›Paper›PMID 42498785›Full record

ArticleThe Journal of antibiotics2026

Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp.

Shotaro Hoshino, Emiko Nagai, Hisayuki Komaki, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shotaro HoshinoDepartment of Life Science, Faculty of Science, Gakushuin University, Toshima, Japan. shotaro.hoshino@gakushuin.ac.jp.ORCID http://orcid.org/0000-0002-7502-5072
Emiko NagaiGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Japan.
Hisayuki KomakiBiological Resource Center, National Institute of Technology and Evaluation (NBRC), Kisarazu, Japan.
Shinta IjichiDepartment of Life Science, Faculty of Science, Gakushuin University, Toshima, Japan.
Shumpei AsamizuEngineering Biology Research Center, Kobe University, Kobe, Japan.ORCID http://orcid.org/0000-0002-7178-5410
Hiroyasu OnakaDepartment of Life Science, Faculty of Science, Gakushuin University, Toshima, Japan. hiroyasu.onaka@gakushuin.ac.jp.ORCID http://orcid.org/0000-0003-4536-1881

Funding

Japan Agency for Medical Research and Development (AMED) JP19nk0101397Japan Agency for Medical Research and Development (AMED) JP23nk0101525
6 · The paper itself

Abstract

Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, and the structure of 2 was further confirmed by chemical synthesis. Based on disk diffusion and broth microdilution assays using the synthetic material, 2 exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeast.

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.