Evidence map›Paper›PMID 42498777›Full record

ArticleEye (London, England)2026

Short-term efficacy and safety of transcleral lutein iontophoresis in patients with intermediate amd and reticular pseudodrusen: A retrospective study.

Mutasem Elfalah, Enrico Borelli, Paola Marolo, Michele Reibaldi, Vincenco De Angelis, Carlo De Rosa, Francesco Iatì, Niccolò Castellino, Sandrine Anne Zweifel, Yacoub A Yousef and 7 more

Abstract read
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Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mutasem ElfalahDepartment of Special Surgery, Ophthalmology Unit, The University of Jordan, 11941, Amman, Jordan.ORCID http://orcid.org/0000-0002-9677-6203
Enrico BorelliDepartment of Surgical Sciences, Section of Ophthalmology, University of Turin, 10126, Turin, Italy.ORCID http://orcid.org/0000-0003-2815-5031
Paola MaroloDepartment of Surgical Sciences, Section of Ophthalmology, University of Turin, 10126, Turin, Italy.
Michele ReibaldiDepartment of Surgical Sciences, Section of Ophthalmology, University of Turin, 10126, Turin, Italy.
Vincenco De AngelisUOC di Oftalmologia, Ospedale A. Cardarelli, 80131, Naples, Italy.
Carlo De RosaDepartment of Ophthalmology, University of Naples Federico II, 80131, Naples, Italy.
Francesco IatìDepartment of Ophthalmology, University of Naples Federico II, 80131, Naples, Italy.
Niccolò CastellinoDepartment of Ophthalmology, University of Catania, 95123, Catania, Italy.ORCID http://orcid.org/0000-0003-1818-6686
Sandrine Anne ZweifelDepartment of Ophthalmology, University Hospital Zurich, 8091, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7431-1774
Yacoub A YousefDepartment of Surgery/Ophthalmology, King Hussein Cancer Centre (KHCC), 11941, Amman, Jordan.
Daniela BacheriniEye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, 50134, Florence, Italy.
Andrea LucisanoDepartment of Medical and Surgical Sciences, Azienda Ospedaliero-Universitaria R. Dulbecco, University Magna Græcia of Catanzaro, Catanzaro, 88100, Italy.
Adriano CarnevaliDepartment of Medical and Surgical Sciences, Azienda Ospedaliero-Universitaria R. Dulbecco, University Magna Græcia of Catanzaro, Catanzaro, 88100, Italy.
Robert RejdakDepartment of General and Pediatric Ophthalmology, Medical University of Lublin, 20079, Lublin, Poland.
Giuseppe GiannaccareEye Clinic, Department of Surgical Sciences, University of Cagliari, 09124, Cagliari, Italy.
Vincenzo ScorciaDepartment of Medical and Surgical Sciences, Azienda Ospedaliero-Universitaria R. Dulbecco, University Magna Græcia of Catanzaro, Catanzaro, 88100, Italy.
Mario Damiano ToroDepartment of Special Surgery, Ophthalmology Unit, The University of Jordan, 11941, Amman, Jordan. mariodamiano.toro@unina.it.ORCID http://orcid.org/0000-0001-7152-2613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited data available on the efficacy and safety of Transscleral Lutein Iontophoresis (TSLI) in patients with intermediate age-related macular degeneration (iAMD) and reticular pseudodrusen (RPD).

methodsThis retrospective multicentre study evaluated the functional and morphological outcomes of TSLI in patients with stage 2 and stage 3 iAMD with RPD. Autofluorescence (AF), Optical Coherence Tomography (OCT), Best Corrected Visual Acuity (BCVA), Intraocular Pressure (IOP), Macular Sensitivity (MS) and adverse events, were recorded at baseline, 1 month and 3 months follow-up after treatment.

resultsThirty eyes from 30 patients, (15 ♂: 15 ♀), mean age (70.3 ± 7.8 years) were included. BCVA improved significantly, from mean baseline 65.6 ± 8.6 ETDRS letters to 66.9 ± 8.0 at 1 month and 69.1 ± 7.8 at 3 months (ANOVA, p < 0.0001, respectively), along with MS, (ANOVA p < 0.001). There was a significant increase of stage 1 RPD (p = 0.002) and a decrease in stage 3 RPD (p = 0.020). The Outer Nuclear Layer (ONL) thickness increased significantly (ANOVA, p < 0.0001). No adverse events were recorded.

conclusionTSLI appears to be an effective, safe technique in patients with iAMD and RPD, leading to structural and functional improvements in short-term follow-up.

Identifiers

PMID42498777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.