Evidence map›Paper›PMID 42498718›Full record

ArticleScientific reports2026

Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide.

Kahona Zushi, Miyumi Seki, Ryota Mizuochi, Kazuki Shitamitsu, Alaa Elgaabari, Sakiho Tanaka, Junri Miyamoto, Kaoru Mizoguchi, Reina Fujimaru, Jiaxi Han and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kahona Zushi *Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0008-7908-015X
Miyumi Seki *Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0007-7419-3932
Ryota MizuochiDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0009-5925-4789
Kazuki ShitamitsuDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0003-0775-2643
Alaa ElgaabariDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0000-0003-4457-0809
Sakiho TanakaDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0009-7592-2863
Junri MiyamotoDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0002-4789-5633
Kaoru MizoguchiDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0002-3979-6272
Reina FujimaruDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0001-9523-4488
Jiaxi HanDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0004-4092-9815
Takashi NakashimaDepartment of Bioscience and Biotechnology, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0000-0002-3881-4195
Shoko SawanoDepartment of Food and Life Science, School of Life and Environmental Science, Azabu University, Sagamihara, 252-5201, Japan.ORCID 0000-0002-8568-483X
Wataru MizunoyaDepartment of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan.ORCID 0000-0002-2258-1964
Takahiro MaenoDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0009-0008-6629-3447
Issei YokoyamaDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0000-0002-1998-0200
Takahiro SuzukiDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID 0000-0002-7949-5477
Judy E AndersonDepartment of Biological Sciences, Faculty of Science, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.ORCID 0000-0001-5552-4010
Ryuichi TatsumiDepartment of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, West Zone 5, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan. rtatsumi@agr.kyushu-u.ac.jp.ORCID 0000-0001-9223-0636

Funding

Japan Society for the Promotion of Science JP26660218, JP21H02347, JP24K01911Japan Society for the Promotion of Science P22389
6 · The paper itself

Abstract

Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO

Indexed as

Hepatocyte Growth FactorProto-Oncogene Proteins c-metSulfidesThioctic AcidAnimalsGlutathioneMicePeroxynitrous AcidProtein BindingTyrosineGlutathioneHepatocyte Growth FactorPeroxynitrous AcidProto-Oncogene Proteins c-metSulfidesThioctic AcidTyrosineC-Met binding affinityHepatocyte growth factor (HGF)Lipoic acid trisulfide (LASSS)Mouse and ratMuscle atrophyPeroxynitriteResident myogenic stem satellite cellTyrosine nitration

Identifiers

PMID42498718
PMCPMC13400622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.