Evidence map›Paper›PMID 42498697›Full record

ArticleChemMedChem2026

Influence of N-Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease.

Galina F Makhaeva, Tatiana Y Astakhova, Maria V Grishchenko, Tatiana S Shteinberg, Nadezhda V Kovaleva, Natalia P Boltneva, Elena V Rudakova, Pavel G Pronkin, Elena N Timokhina, Eugene V Radchenko and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Galina F MakhaevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0002-8136-6906
Tatiana Y AstakhovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0002-3034-9698
Maria V GrishchenkoPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia.ORCID https://orcid.org/0000-0003-4110-2620
Tatiana S ShteinbergInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0009-0007-6094-8070
Nadezhda V KovalevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0002-4990-5068
Natalia P BoltnevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0002-7171-8832
Elena V RudakovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0002-4600-7799
Pavel G PronkinInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID https://orcid.org/0000-0003-1483-106X
Elena N TimokhinaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0003-2953-1705
Eugene V RadchenkoDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID https://orcid.org/0000-0002-2091-7022
Evgeny V ShchegolkovPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia.ORCID https://orcid.org/0000-0001-6611-2855
Yanina V BurgartPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia.ORCID https://orcid.org/0000-0001-6061-2410
Victor I SaloutinPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia.ORCID https://orcid.org/0000-0003-1976-7861
Valery N CharushinPostovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia.ORCID https://orcid.org/0000-0002-9140-358X
Rudy J RichardsonDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-2028-5723

Funding

Russian Science Foundations 24-63-00016
6 · The paper itself

Abstract

The goal of this mechanistic study was to elucidate the influence of N-functionalization of amiridine on the biological properties of its conjugates. We synthesized conjugates of amiridine and salicylimine/amine 9, 10 with linkers containing an N-acyl group at the amiridine fragment as analogs of our previously obtained hybrids 1, 2 containing an N-aminohexamethylene spacer. A comparative study of selected biological activities of N-acylalkylene conjugates 9, 10 with conjugates 1, 2 showed substantial decreases in anti-butyrylcholinesterase (BChE) activity (35-fold for the imine and 8-fold for the amine), loss of anti-acetylcholinesterase (AChE) activity, and disappearance of the ability to block amyloid beta (1-42) (Aβ

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsAcetylcholinesteraseAmyloid beta-PeptidesButyrylcholinesteraseHumansIminesMolecular Docking SimulationMolecular StructurePeptide FragmentsStructure-Activity RelationshipAcetylcholinesteraseAmyloid beta-Peptidesamyloid beta-protein (1-42)ButyrylcholinesteraseCholinesterase InhibitorsIminesPeptide FragmentsAlzheimer's diseaseamiridinemultitarget agentsN‐functionalizationsalicylimine/amine

Identifiers

PMID42498697
PMCPMC13400319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.