ArticleInfluenza and other respiratory viruses2026
Contribution of E190D and Q226H Mutations in HA to the Receptor-Binding Profile of D1.1 Genotype H5N1 Viruses.
Yang Fang, Lei Yang, Shumei Zou, Liqi Liu, Wenfei Zhu, Dayan Wang
Abstract read
In one paragraphArticle in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors.
Yang FangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.ORCID https://orcid.org/0009-0005-7925-7793 Lei YangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.
Shumei ZouNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.
Liqi LiuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.
Wenfei ZhuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.
Dayan WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese Academy of Preventive Medicine), Beijing, China.
Funding
National Key Research and Development Program of China 2025YFC2311700Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project 2025ZD01903200
6 · The paper itselfAbstract
A 2024 human HPAI H5N1 case in British Columbia showed mixed viral populations containing HA-190D (28%) and HA-226H (35%) variants in tracheal aspirate sequencing. In this study, solid-phase binding assay and molecular docking were used to evaluate the contribution of HA-E190D/Q226H mutations to the viral receptor profiles. Our results showed that HA-E190D marginally reduced sialic acid α2,3 receptors' affinity, while HA-Q226H impaired both sialic acid α2,3 and α2,6 receptors' binding. These results demonstrate that neither mutation strengthens viral binding to human-type receptors, indicating that such substitutions are unlikely to heighten the public health threat posed by the virus for now.
Indexed as
Hemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H5N1 SubtypeMutation, MissenseReceptors, VirusVirus AttachmentAmino Acid SubstitutionGenotypeHumansInfluenza, HumanMolecular Docking SimulationMutationProtein BindingHemagglutinin Glycoproteins, Influenza VirusReceptors, VirusE190DHPAI H5N1public health threatQ226Hreceptor profile
Identifiers
PMID42498495
PMCPMC13400179
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