Evidence map›Paper›PMID 42497852›Full record

ArticleDevelopmental cell2026

Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots.

Lahong Xu, Fausto Andres Ortiz-Morea, Sung-Il Kim, Camilla Ferrari, Yan Yan, Derui Liu, Daniel Osorio Hurtado, James J Cai, Klaas Vandepoele, Libo Shan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lahong XuDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Fausto Andres Ortiz-MoreaDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Amazonian Research Center Cimaz-Macagual, University of the Amazon, Florencia 180002, Colombia. Electronic address: fauortiz@umich.edu.
Sung-Il KimDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Camilla FerrariDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium.
Yan YanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Derui LiuDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Daniel Osorio HurtadoDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
James J CaiDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Klaas VandepoeleDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium; VIB Center for AI & Computational Biology, VIB, 9052 Ghent, Belgium.
Libo ShanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ping HeDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: pinghemi@umich.edu.

Funding

Immune signal perception and integration by cell surface receptors and peptide ligandsR35GM144275 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Libo Shan · 2022 to 2026
$2.2M
Signaling activation and constraints in maintaining immune homeostasisR35GM149197 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ping He · 2023 to 2026
$1.2M
NIGMS NIH HHS R35 GM144275NIGMS NIH HHS R35 GM149197
6 · The paper itself

Abstract

Roots, composed of diverse cell types across longitudinal developmental zones, are vital for plant survival against microbial challenges. Leveraging single-cell transcriptomics and live-cell imaging of Arabidopsis roots, we reveal here that plant-derived phytocytokines elicit more potent immune responses than microbe-derived patterns across root cell types and zones. The differential expression of receptors and key signaling modules in distinct cell types and zones contributes to the response intensity to specific elicitors. Phytocytokines sustain growth-defense trade-offs by suppressing the expression of receptor-like kinase genes associated with root cell division and elongation. The intensity of immune responses in different root zones is associated with fungal and bacterial pathogen invasion sites. Furthermore, motif-informed network inference highlighted key transcriptional regulators driving cell identity-specific transcriptomic immune responses. Our study provides a comprehensive landscape of transcriptional responses in plant roots in response to diverse immune elicitors, highlighting how distinct phytocytokines orchestrate stage- and cell type-dependent transcriptional reprogramming.

Indexed as

ArabidopsisPlant ImmunityPlant RootsArabidopsis ProteinsGene Expression Regulation, PlantInnate Immunity RecognitionSignal TransductionTranscriptomeArabidopsis Proteinsgene regulatory networklive-cell imagingmicrobe-associated molecular patternsphytocytokinesroot immunitysingle-cell transcriptomics

Identifiers

PMID42497852
PMCPMC13450817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.