ArticleEmerging microbes & infections2026
Longitudinal in vivo imaging reveals asynchronous, incomplete Nipah virus clearance with prolonged focal CNS involvement in IFNAR
Katherine A Davies, Stephen R Welch, Joann D Coleman-McCray, Georgia Ficarra, Jana M Ritter, Teresa E Sorvillo, Virginia Aida-Ficken, Shilpi Jain, César G Albariño, Joel M Montgomery and 3 more
Abstract read
In one paragraphArticle in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Katherine A DaviesCDC Foundation assigned to Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-1643-7093 Stephen R WelchViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-6905-8521 Joann D Coleman-McCrayViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-0396-2224 Georgia FicarraInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-1210-8516 Jana M RitterInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-4768-162X Teresa E SorvilloCDC Foundation assigned to Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-2943-4040 Virginia Aida-FickenViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-9450-0142 Shilpi JainViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-5638-0298 César G AlbariñoViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-8013-1785 Joel M MontgomeryViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-0523-4431 Michael K LoViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-0409-7896 Christina F SpiropoulouViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-8406-3161 Jessica R SpenglerViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-5383-0513 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Nipah virus (NiV) infection causes fatal acute respiratory and neurological disease. Survivors may develop long-term sequelae or experience relapsing encephalitis months to years after recovery. The basis of divergent disease trajectories and incomplete viral clearance remains poorly defined. Here, we establish a red-shifted bioluminescent resonance energy transfer reporter system to enable longitudinal tracking of NiV infection in vivo and apply it in mouse models of infection. We demonstrate route-, strain-, and immune-dependent differences in dissemination following NiV infection and reveal spatially heterogeneous and asynchronous viral clearance. While intranasal infection remains largely confined to the respiratory tract, intraperitoneal infection results in systemic spread followed by prolonged, fluctuating focal viral signal detectable up to 42 days post-infection in IFNAR
Indexed as
Henipavirus InfectionsNipah VirusReceptor, Interferon alpha-betaAnimalsBrainDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutIfnar1 protein, mouseReceptor, Interferon alpha-betabioluminescence imagingcentral nervous system infectionsmiceNipah virusviral persistence
Identifiers
PMID42497356
PMCPMC13403577
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