Evidence map›Paper›PMID 42497353›Full record

ArticleEmerging microbes & infections2026

Seminal fluid enhances monkeypox virus infection via amyloidogenic fibrils.

Emma Torbica, Matthias Denkewitz, Tamara Quick, Nadja Zöller, Katja Steinhorst, Stefan Kippenberger, Florian Rothweiler, Jindrich Cinatl, Pia Veratti, Florian Full and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emma TorbicaInstitute of Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Matthias DenkewitzInstitute of Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Tamara QuickInstitute of Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Nadja ZöllerDepartment of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Katja SteinhorstDepartment of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Stefan KippenbergerDepartment of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Florian RothweilerDr Petra Joh-Haus, Frankfurter Stiftung für krebskranke Kinder, Frankfurt (Main), Germany.
Jindrich CinatlDr Petra Joh-Haus, Frankfurter Stiftung für krebskranke Kinder, Frankfurt (Main), Germany.
Pia VerattiFaculty of Medicine, Institute of Virology, University Medical Center, Albert-Ludwig-University Freiburg, Freiburg, Germany.
Florian FullFaculty of Medicine, Institute of Virology, University Medical Center, Albert-Ludwig-University Freiburg, Freiburg, Germany.
Undraga SchagdarsurenginMolecular Andrology, Clinic of Urology, Pediatric Urology and Andrology, Justus-Liebig-University Giessen, Giessen, Germany.
Sandra CiesekInstitute of Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Jan MünchInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.ORCID 0000-0001-7316-7141
Janis A MüllerInstitute of Virology, Philipps University Marburg, Marburg, Germany.
Denisa BojkovaInstitute of Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mpox is a re-emerging zoonosis caused by monkeypox virus (MPXV), with recent outbreaks driven by sexual transmission. How semen contributes to MPXV infection, however, remains unclear. Here, we show that human seminal fluid potently enhances MPXV infection in susceptible target cells. Pre-exposure of MPXV to seminal fluid from multiple donors markedly increased infection of primary human fibroblasts and keratinocytes. Semen-derived peptide fragments that assemble into cationic amyloid fibrils (SEVI and SEM) enhanced infection of epithelial cells, primary monocytes, and ex vivo human skin, as well as clinical MPXV isolates and other

Indexed as

AmyloidMonkeypox virusMpox, MonkeypoxSemenBridged-Ring CompoundsEpithelial CellsFibroblastsHumansKeratinocytesMaleOrganophosphatesAmyloidBridged-Ring CompoundsCLR01 compoundOrganophosphatesmolecular tweezerMpoxMPXVsemenSEVIsexual transmission

Identifiers

PMID42497353
PMCPMC13403458

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.