Evidence map›Paper›PMID 42497280›Full record

ArticleScience advances2026

A genetically encoded sensor of ionic stress links cellular proton dynamics to sleep.

Zhijian Ji, Bingying Wang, Zhimin Ma, Lina Verbakel, Junqiang Liu, Yanchang Bian, Wenjie Zeng, Chan-I Chung, Shuaian Wei, Jianxiu Zhang and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhijian JiCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0005-6314-0961
Bingying WangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Zhimin MaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Lina VerbakelNagi Bioscience SA, Rue des Jordils 1A, 1025 Saint-Sulpice, Switzerland.ORCID 0000-0003-0490-8406
Junqiang LiuCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2953-487X
Yanchang BianCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Wenjie ZengCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Chan-I ChungCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Shuaian WeiCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0009-0319-3921
Jianxiu ZhangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1864-7510
Supeng YangDepartment of Molecular Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0005-4357-9483
Morgane BourgeoisNagi Bioscience SA, Rue des Jordils 1A, 1025 Saint-Sulpice, Switzerland.ORCID 0009-0002-6469-2838
Laurent MouchiroudNagi Bioscience SA, Rue des Jordils 1A, 1025 Saint-Sulpice, Switzerland.ORCID 0009-0000-1979-9105
Xiaokun ShuCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9248-7095
Dengke K MaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5619-7485

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
EQUIPMENT for Designing a new class of fluorescent reporters for imaging dynamic cell signaling in live animalsR35GM131766 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHU, XIAOKUN · 2019 to 2025
$4.0M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
Dissecting functional roles of MeCP2 condensates in neurons with chemogenetic toolsR21DA056293 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHEN, YIN · 2022 to 2023
$444k
NIDA NIH HHS R21 DA056293NIGMS NIH HHS R35 GM131766NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440
6 · The paper itself

Abstract

Although biosensors for specific cellular ions are widely available, real-time monitoring of overall ionic strength in living organisms remains challenging. Here, we present a genetically encoded nuclear translocation ionic sensor (GENTIS) that enables direct visualization of ionic stress in vivo. Using this sensor alongside longitudinal tracking via an automated microfluidic platform, we find that

Indexed as

Biosensing TechniquesCaenorhabditis elegansProtonsSleepStress, PhysiologicalAnimalsLarvaOsmolar ConcentrationVacuolar Proton-Translocating ATPasesProtonsVacuolar Proton-Translocating ATPases

Identifiers

PMID42497280
PMCPMC13398478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.