Evidence map›Paper›PMID 42497270›Full record

ArticleScience advances2026

Above-twofold quantum super-resolution microscopy enabled by multiple idler passes with entangled biphotons.

Xin Tong, Zhe He, Yide Zhang, Wenyu Liu, Chien-Ying Huang, Lihong V Wang

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin TongCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.ORCID 0000-0003-2002-5638
Zhe HeCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.ORCID 0000-0002-8525-3650
Yide ZhangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.ORCID 0000-0002-9463-3970
Wenyu LiuCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.
Chien-Ying HuangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd., MC 138-78, Pasadena, CA 91125, USA.ORCID 0000-0001-9783-4383

Funding

High-speed panoramic 3D photoacoustic computed tomography of the breastR35CA220436 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, LIHONG · 2018 to 2024
$6.4M
UCLA and Caltech integrated Cardiovascular Medicine for Bioengineers (iCMB)T32HL144449 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, PAJUKANTA, PAIVI · 2020 to 2024
$1.2M
Next-generation photoacoustic imaging for real-time, non-invasive monitoring of brain oxygen metabolismK99EB035645 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ZHANG, YIDE · 2024 to 2024
$127k
NCI NIH HHS R35 CA220436NHLBI NIH HHS T32 HL144449NIBIB NIH HHS K99 EB035645
6 · The paper itself

Abstract

Spatial resolution defines the fundamental limit of how precisely optical imaging systems can distinguish details within an object. Recent advances in quantum imaging have surpassed classical resolution limits by exploiting entanglement. However, experimental demonstrations of quantum enhancement above two times using entangled biphotons have thus far been limited to nonimaging experiments that use replication of the object or nonlinearity-both are impractical and inefficient. Here, without resorting to either, we enhance the classical resolution using entangled photon pairs by either two- or fourfold in two system configurations. While the signal photons traverse the object-containing arm only once, the idler photons traverse the symmetric object-free arm either once or thrice. These experiments demonstrate a scalable route toward quantum-correlated super-resolution imaging, motivate theoretical exploration of the underlying mechanisms, and open opportunities for high-precision, low-illumination microscopy.

Identifiers

PMID42497270
PMCPMC13398480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.