Evidence map›Paper›PMID 42497254›Full record

ArticleScience advances2026

N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases.

Eunjeong Lee, Jasmina S Redzic, Samrat Sarkar, Daniel Rivkin, Blaine Gordon, Anthony J Saviola, Sean P Maroney, John C Thorstenson, Kirk C Hansen, Alexander R Horswill and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eunjeong LeeDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-0560-2943
Jasmina S RedzicDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Samrat SarkarDepartment of Chemistry, Georgia State University, Atlanta, GA 30302-3965, USA.ORCID 0009-0003-7210-4407
Daniel RivkinDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0009-0008-5125-8374
Blaine GordonDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Anthony J SaviolaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0001-6890-512X
Sean P MaroneyDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0009-0003-0483-175X
John C ThorstensonDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0009-0005-9054-7724
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0001-5054-838X
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-5568-0096
Donald HamelbergDepartment of Chemistry, Georgia State University, Atlanta, GA 30302-3965, USA.ORCID 0000-0002-3785-3037
Elan EisenmesserDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-6967-0892

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Staphylococcus aureus induced itch and neuro-immune signaling in skin infectionsR01AI168005 · NIAID · HARVARD MEDICAL SCHOOL · PI Isaac Ming-Cheng Chiu, ALEXANDER R HORSWILL · 2022 to 2026
$3.7M
Developing computational tools to complement experiments in understanding biomolecular function from conformational ensemblesR35GM153718 · NIGMS · GEORGIA STATE UNIVERSITY · PI Donald Hamelberg · 2024 to 2026
$1.2M
900 MHz NMR console and probesS10OD034299 · OD · UNIVERSITY OF COLORADO DENVER · PI JONES, DAVID NIGEL · 2023 to 2023
$1.1M
The Molecular Basis of Staphylococcus aureus SplB manipulation of the hostR01AI189606 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ELAN Z EISENMESSER · 2025 to 2026
$780k
600 MHz NMR console and cold probeS10OD025020 · OD · UNIVERSITY OF COLORADO DENVER · PI JONES, DAVID NIGEL · 2018 to 2018
$501k
Streptococcus pneumoniae HtrA and its target interactionsR21AI190731 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ELAN Z EISENMESSER · 2025 to 2026
$423k
BLRD VA I01 BX002711NCI NIH HHS P30 CA046934NIAID NIH HHS R01 AI168005NIAID NIH HHS R01 AI189606NIAID NIH HHS R21 AI190731NIGMS NIH HHS R35 GM153718NIH HHS S10 OD025020NIH HHS S10 OD034299
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsMethicillin-Resistant Staphylococcus aureusSerine ProteasesStaphylococcus aureusAllosteric RegulationCatalytic DomainMolecular Dynamics SimulationProtein BindingProtein ConformationSubstrate SpecificityBacterial ProteinsSerine Proteases

Identifiers

PMID42497254
PMCPMC13398530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.