Evidence map›Paper›PMID 42497072›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Bidirectional Modulation of the Tumor Immune Microenvironment by Gut Microbiota-Derived Indoles: Mechanisms and Therapeutic Potential.

Chaowei Wang, Ling Bi, Yan Wang

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chaowei WangThe Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine, Guizhou, China.ORCID https://orcid.org/0009-0009-0841-827X
Ling BiDepartment of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan WangThe Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine, Guizhou, China.

Funding

Open Foundation of Chinese Medicine Guangdong Laboratory HQL2025OPA016Shanghai Frontier Research Base of Disease and Syndrome Biology of Inflammatory Cancer Trans-formation 2021KJ03-12Special Funds for High-level Creative Talents Cultivation in Guizhou Province Qian Ke He XKBF (2025)027The National Natural Science Foundation of China 82474230
6 · The paper itself

Abstract

The tumor immune microenvironment (TIME) plays a decisive role in cancer progression and therapeutic response. Emerging evidence highlights gut microbiota-derived indole metabolites, produced from dietary tryptophan, as key regulators of tumor immunity. These metabolites function through complex metabolic networks and exert dual immunomodulatory effects: they can enhance antitumor immunity by promoting CD8

Indexed as

Gastrointestinal MicrobiomeIndolesNeoplasmsTumor MicroenvironmentAnimalsHumansIndolescancergut microbiomeimmuneindolemetabolite

Identifiers

PMID42497072
PMCPMC13399188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.