Evidence map›Paper›PMID 42496893›Full record

ArticleSurgery today2026

Clinical impact of the prognostic nutritional index at listing and immediately before surgery in lung transplantation.

Shinji Yuhara, Gouji Toyokawa, Junichi Takada, Miho Yamaguchi, Yue Cong, Takaki Akamine, Masahiro Yanagiya, Takahiro Karasaki, Mitsuaki Kawashima, Chihiro Konoeda and 2 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Shinji YuharaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Gouji ToyokawaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Junichi TakadaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Miho YamaguchiDepartment of Respiratory Medicine, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yue CongDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takaki AkamineDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Masahiro YanagiyaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takahiro KarasakiDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Mitsuaki KawashimaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Chihiro KonoedaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yan LuoDepartment of Next-Generation Organ Transplantation, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. SATOM-SUR@h.u-tokyo.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prognostic nutritional index (PNI), which is calculated from the serum albumin concentrations and lymphocyte counts, predicts the outcomes in lung transplantation (LT). This study aimed to investigate the optimal timing for assessing PNI before LT.

methodsWe analyzed 140 brain-dead LT recipients (2015-2023) in this study. The PNI was calculated at the time of transplant listing and immediately before LT. Using a cutoff value of 45, the patients were classified into high/low PNI groups and compared for overall survival. Changes in the PNI trajectories were analyzed.

resultsMultivariable analyses showed that a low PNI independently predicted mortality at listing (hazard ratio [HR], 2.82; 95% confidence interval [CI], 1.44-5.53; P = 0.003) and before LT (HR, 2.44; 95% CI, 1.25-4.77; P = 0.009). Patients with a persistently low PNI had a worse survival than those with a persistently high PNI (HR, 3.58; 95% CI, 1.62-7.91; P = 0.002), whereas an improvement in the PNI after listing was not significantly associated with survival.

conclusionPNI at both time points significantly predicted post-transplant outcomes. A trajectory analysis highlights the importance of nutritional assessment before listing, although larger studies are required to clarify the effects of nutritional changes after listing.

Indexed as

Lung transplantationNutritionPrognostic nutritional indexSurvivalWaiting list

Identifiers

PMID42496893

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