Evidence map›Paper›PMID 42496867›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026

Comparative performance of open thorax epicardial linear cryoprobe ablation versus focal tip radiofrequency catheter ablation in ventricular scar.

Justin Hayase, Rami Aladham, Min Zhang, Gregory A Fishbein, Takanori Sato, Shumpei Mori, Kalyanam Shivkumar, Olujimi A Ajijola, Jason S Bradfield

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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justin HayaseUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA. justin.hayase@gmail.com.ORCID http://orcid.org/0000-0001-9242-3817
Rami AladhamUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Min ZhangUCLA Department of Pathology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Gregory A FishbeinUCLA Department of Pathology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Takanori SatoUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Shumpei MoriUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Kalyanam ShivkumarUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Olujimi A AjijolaUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Jason S BradfieldUCLA Cardiac Electrophysiology Division, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpicardial cryoablation is increasingly utilized in open surgical procedures for treatment of ventricular arrhythmias in patients with structural heart disease when percutaneous epicardial access cannot be obtained. There are limited data regarding the effects of cryoablation within ventricular scar tissue, particularly in comparison to the performance of radiofrequency (RF) catheter ablation. This study aimed to investigate the comparative performance of ablation delivered epicardially in an open chest animal model with a linear cryoprobe versus a radiofrequency catheter.

methodsAn infarct model was created in five Yorkshire swine using microsphere injection into the left anterior descending artery. After 6-8 weeks, animals underwent median sternotomy with targeted epicardial RF ablation lesions, and linear cryoablation lesions were delivered to myocardial infarct scar regions. Specimens were pressure perfused with 10% formalin, and histological analysis was performed.

resultsOut of 25 epicardial RF lesions, 13 were visible and able to be analyzed. All 15 epicardial cryoablation lesions were visible. All 15 cryoablation lesions had transmural effect within scar where tissue thickness was ≤6 mm, whereas only 62% of evaluable RF lesions were transmural in scar (p = 0.01). Average cryoablation lesion depth was 4.2 ± 1.1 mm in scar and 5.6 ± 1.4 mm in border zone.

conclusionLinear epicardial cryoablation is a useful tool in open surgical procedures to treat ventricular arrhythmias in structural heart disease. Cryoablation can achieve transmurality in tissue with ≤ 6 mm thickness with more technically reliable effect compared to catheter RF in the open chest.

Indexed as

Border zoneCatheter ablationCryoablationMyocardial scar

Identifiers

PMID42496867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.