ArticleMolecular neurobiology2026
Functional and Transcriptional Downregulation of Glutamate Transporters (EAAT1 and EAAT2) via DNMT3B Overexpression in Glial Cells.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glutamate (Glu) is the major excitatory neurotransmitter amino acid in the vertebrate brain. It elicits its actions through the activation of specific receptors in neurons and glial cells. Excitatory amino acid transporters 1 and 2 are the Glu transporters expressed in glial cells, responsible for recycling Glu and executing a protective role against excitotoxicity and neurodegeneration. In neurogenerative diseases and gliomas, glial cells fail to maintain Glu-glutamine homeostasis, triggering excitotoxicity and DNA methylation profile disruption. The aim of this contribution was to investigate the relationship between the methylation gained by DNA methylase 3B overexpression and the functional effect and the expression levels of Glu transporters in glial cell models. First, we confirmed the differential expression and deregulation of excitatory amino acid transporters 1 and 2 in cancer and neurodegenerative diseases. Next, Müller retinal cells were transfected with a DNA methylase 3B vector, and global 5-methylcytosine increased was detected after 48 h. Using a [
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