ArticleJACC. Asia2026
TNNT2 Mutation Affects the Progression of Dilated Cardiomyopathy in Children.
Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- TNNT2 Mutation in Pediatric Dilated Cardiomyopathy: Implications for Early Genetic Screening.JACC. Asia · 2026Article
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12 authors.
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Abstract
backgroundGenetic mutations play an important role in pediatric cardiomyopathy. However, whether different genetic factors contribute to the rate of disease progression remains unclear.
objectivesThe authors aimed to explore the role of genetic mutations in disease progression in pediatric cardiomyopathy.
methodsWe collected basic clinical data on 67 children and 166 adults who underwent heart transplantation for cardiomyopathy, and conducted whole-exome sequencing and standard pathology examinations on these patients. We then compared the prevalence of pathogenic genes and their occurring in the same type of myocardium between children and adult heart transplantation recipients, with a focus on the age of onset and duration of disease.
resultsOf 67 children, 33 (49.3%; 95% CI: 32.2%-55.3%) carried mutation genes. The proportion of mutations varied significantly among different types of cardiomyopathies (P = 0.003). The median [IQR] time from diagnosis to transplant was significantly shorter in children compared to adults in cases of dilated cardiomyopathy (DCM) (12 [1-23] vs 103 [5-201] months, P < 0.001), hypertrophic cardiomyopathy (32 [14.5-46.5] vs 234 [183-285] months, P = 0.002) and arrhythmogenic cardiomyopathy (28 [14.5-41.5] vs 127 [86-168] months, P < 0.001). Children with DCM were more likely to carry the TNNT2 mutation compared to adults with DCM (P = 0.001), and heart failure progressed more rapidly in children with this mutation versus adults (19 vs 128 months, P = 0.002). The most common mutation site in these children was p.K220del.
conclusionsTNNT2 mutations were associated with shorter time from diagnosis to transplantation in children with DCM. These findings suggest that early genetic evaluation may aid in risk stratification and inform clinical management in pediatric cardiomyopathy.
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