ArticleJournal of virology2026
Identification of TMEM41B TM6 as a critical domain for coronavirus replication
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Transmembrane protein 41B (TMEM41B) serves as a critical host factor for various coronavirus infections, providing a potential target for developing antiviral gene-edited animals. However, TMEM41B is a gene essential for mammalian embryonic development, with complete knockout resulting in embryonic lethality. Consequently, it is of paramount importance to identify its critical functional domains that are amenable to deletion. In this study, we demonstrated that TMEM41B is involved in the replication stage of porcine deltacoronavirus (PDCoV), an emerging zoonotic coronavirus that infects various animals and even humans, but not in the attachment, internalization, or release steps. Through the construction of truncated mutants and cell lines stably expressing or precisely lacking the functional domains of TMEM41B, we confirm that, in addition to the VTT domain, the sixth transmembrane (TM6) domain of TMEM41B is also required for coronavirus infection. Using CRISPR/Cas9 technology, we generated a C57BL/6J mouse model with a deletion of the TMEM41B TM6 domain. Animal experiments demonstrated that the deletion of the TM6 domain significantly inhibited viral infection
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