Evidence map›Paper›PMID 42496102›Full record

ArticleCNS neuroscience & therapeutics2026

Unraveling the Individualized Shared and Distinct Dynamic Functional Connectivity in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome.

Boli Pan, Junbo Wang, Danyong Feng, Yiting Zhu, Ning Tang, Dongyun Li, Qiong Xu, Rihui Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Boli PanCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau, SAR, China.ORCID https://orcid.org/0009-0007-8182-1909
Junbo WangDepartment of Radiology, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0008-4712-1068
Danyong FengCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau, SAR, China.ORCID https://orcid.org/0009-0009-7279-8705
Yiting ZhuDepartment of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0008-1153-9307
Ning TangDepartment of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.
Dongyun LiDepartment of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0002-9176-0322
Qiong XuDepartment of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-8065-8766
Rihui LiCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau, SAR, China.ORCID https://orcid.org/0000-0001-8006-7333

Funding

Med+X cross-disciplinary team project of the Children's Hospital of Fudan UniversityNatural Science Foundation of Guangdong Province 2025A1515010539the academic leaders development program EKXDPY202306the National Natural Science Foundation of China 82301743the Natural Science Foundation of Anhui Province 2308085MH255the Science and Technology Development Fund of the Macao SAR 0010/2023/ITP1the Science and Technology Development Fund of the Macao SAR 0016/2024/RIB1the University of Macau MYRG-CRG2024-00022-ICIthe University of Macau MYRG-GRG2024-00296-ICIthe University of Macau SRG2023-00015-ICI
6 · The paper itself

Abstract

aimsAutism Spectrum Disorder (ASD), a neurodevelopmental disorder, and Fragile X Syndrome (FXS), an X chromosome-linked hereditary neurodevelopmental disorder, exhibit overlapping phenotypes like social impairment and stereotyped behaviors. Previous studies have predominantly explored the functional network characteristics of either FXS or ASD. However, the shared and distinct dynamic neural circuitry underlying both disorders remains unclear, impeding personalized treatment.

methodsThis study examined the shared and distinct temporal topological properties of ASD and FXS, along with their respective patterns of functional network deviation relative to typically developing (TD). A total of 47 FXS children (5.2 ± 2.5 years), 91 ASD children (3.37 ± 1.37 years), and 52 TD children (5.2 ± 2.9 years) were included.

resultsAnalyses revealed both shared hyperconnectivity involving sensorimotor network (SMN), default mode network (DMN), ventral attention-visual network (VAN-VN) connectivity, and subcortical-cerebellum network (SN-CN) and distinct temporal topological features, with temporal metrics differences primarily localized to intermediate activation patterns linked to cognitive switching.

conclusionsAs a large-scale pediatric dFC study comparing FXS and ASD, it advances mechanistic understanding and proposes novel differentiation.

Indexed as

Autism Spectrum DisorderBrainFragile X SyndromeNerve NetBrain MappingChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysASDdynamic functional connectivityFXSnormative modelingpersonalized evaluation

Identifiers

PMID42496102
PMCPMC13398155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.