ReviewRNA biology2026
The Mediator complex: co-transcriptional regulation and beyond.
Review in RNA biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mediator complex functions as a central multi-subunit coactivator essential for RNA polymerase II-dependent transcription in eukaryotes, integrating signals from enhancers to promoters across the transcription cycle. This review summarizes its modular composition and structural dynamics revealed by cryo-EM, and details its mechanistic roles in pre-initiation complex assembly, promoter-proximal pausing release, elongation progression, co-transcriptional splicing, termination via 3'-end processing, and chromatin changes. Recent progress elucidates allosteric signal transmission, TF multivalency, cohesin-mediated looping, and phase separation, while dysregulation implicates Mediator in cancer and developmental disorders. Future directions emphasize in vivo kinetics and therapeutic targeting of kinase modules to decode context-specific gene control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.