Evidence map›Paper›PMID 42496049›Full record

ArticleThoracic research and practice2026

Clinical Significance of Age and Coexisting Lifestyle-related Diseases in ILD Patients with Acute Exacerbation.

Masahiro Uchiyama, Kunihiko Miyazaki, Yosuke Maezawa, Naomi Kayauchi, Shinichiro Okauchi, Hiroaki Satoh, Ryuichi Hasegawa

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Article in Thoracic research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masahiro UchiyamaDepartment of Intensive Care Medicine, Dokkyo Medical University, Saitama Medical Center, Koshigaya, Japan.ORCID 0000-0001-6385-5944
Kunihiko MiyazakiDivision of Respiratory Medicine, Ryugasaki Saiseikai Hospital, Ryūgasaki, Japan.ORCID 0000-0002-7627-3529
Yosuke MaezawaDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba Hospital, Mito, Japan.ORCID 0009-0001-5875-3107
Naomi KayauchiIbaraki Christian University Faculty of Nursing, Hitachi, Japan.ORCID 0009-0008-1377-7042
Shinichiro OkauchiDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba Hospital, Mito, Japan.ORCID 0000-0002-9262-0949
Hiroaki SatohDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba Hospital, Mito, Japan.ORCID 0000-0002-1561-1723
Ryuichi HasegawaDepartment of Intensive Care Medicine, Dokkyo Medical University, Saitama Medical Center, Koshigaya, Japan.ORCID 0000-0002-4041-1002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAs the population ages, the impact of aging and comorbid lifestyle-related diseases on the prognosis of interstitial lung disease (ILD) has not been fully investigated. Therefore, we investigated the impact of age and comorbidities on the prognosis of patients with ILD who experienced acute exacerbations (AEs). MATERIAL AND

methodsWe retrospectively reviewed the medical records and chest computed tomography scans of all consecutive ILD patients, with or without AE, between May 2015 and July 2025. The survival times of cases with and without AE were investigated.

resultsMedian survival time (MST) for 443 ILD cases was 10 years, while the MST for the 158 cases who developed AE was 2 months. The prognosis of cases who developed AE at age 80 years or older was significantly poorer than that of cases younger than 80 years. Among cases younger than 80 years, the survival curve for those who survived 3 months after the onset of AE plateaued. Favorable factors among cases who developed AE were age younger than 80 years and absence of comorbidities such as hypertension, diabetes mellitus, and malignancy.

conclusionFor ILD patients who developed AE, "80 years of age" was the threshold age distinguishing good from poor prognosis. Some patients, particularly those with ILD who were diagnosed early, appeared likely to have an improved prognosis. Some AE patients, particularly younger patients, could be expected to have a good long-term prognosis if they survive a certain period of time.

Indexed as

acute exacerbationagecomorbiditiesInterstitial lung disease

Identifiers

PMID42496049
PMCPMC13687681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.