Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2026
Does a pharmacologically driven elevation in cerebral blood flow modulate cognition during combined hypoxic and thermal stress?
Eloisa Herrera-Ospina, Ernesto Ramirez, Rachel Bailey, Samuel T Stiles, Qudus A Ojikutu, Shiva C Viswanath, Steven R Steinhubl, Shih-Chun Kao, Bruno T Roseguini, Igor A Fernandes
Abstract readRandomized Controlled Trial
In one paragraphTrial report in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Eloisa Herrera-OspinaHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.ORCID 0009-0006-7175-3212 Ernesto RamirezHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.
Rachel BaileyHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.
Samuel T StilesHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.
Qudus A OjikutuHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.ORCID 0009-0009-7045-1329 Shiva C ViswanathDepartment of Health and Kinesiology, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, United States.
Steven R SteinhublWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States.ORCID 0000-0002-9256-7914 Shih-Chun KaoPhysical Activity and NeuroCognitive Health Laboratory, Purdue University, West Lafayette, Indiana, United States.ORCID 0000-0001-8880-0851 Bruno T RoseguiniDepartment of Health and Kinesiology, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, United States.ORCID 0000-0001-7503-5775 Igor A FernandesHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States.ORCID 0000-0003-3873-2656 Funding
Leg heat therapy to improve functional performance in peripheral artery diseaseR01AG073634 · NIA · PURDUE UNIVERSITY · PI Bruno T Roseguini · 2022 to 2026
$2.2MAmerican Heart Association (AHA) Grant No. 24CDA1273371American Physiological Society (APS) Arthur C. Guyton Award for Excellence in Integrative PhysiologyCollege of Health and Human Sciences, Purdue University Health of the ForcesHHS | NIH | National Institute on Aging (NIA) R01 AG073634-01A1NIA NIH HHS R01 AG073634PU | Office of the Executive Vice President for Research and Partnerships, Purdue University (EVPRP) Grace M. Showalter Research Trust Award
6 · The paper itselfAbstract
Cognitive performance during environmental stress is highly variable, and the mechanisms underlying this heterogeneity remain unclear. Cerebral blood flow (CBF) has been proposed as a key determinant of neural performance during hypoxia and heat stress. However, whether experimentally increasing CBF modifies executive function during combined hypoxic and thermal stress has not been directly tested. Thirteen healthy young adults completed a randomized, double-blind, placebo-controlled crossover study. Participants ingested 1,000 mg of acetazolamide (ACZ) or a placebo (PLA) 4 h before testing. CBF was quantified from bilateral internal carotid and vertebral artery blood flow. Executive function was assessed using a Go/No-Go Flanker task during normothermia, hypoxia ([Formula: see text] ≈ 0.10), hyperthermia (+1.5°C to 2.0°C in core temperature), and combined hypoxic-hyperthermic conditions. ACZ increased CBF by ≈200 mL/min (+20% to 32%) across conditions (
Indexed as
Cerebrovascular CirculationCognitionHyperthermiaHypoxiaAcetazolamideAdultCognitive EnhancementCross-Over StudiesDouble-Blind MethodExecutive FunctionFemaleHeat Stress DisordersHumansMaleYoung AdultAcetazolamidecerebral perfusioncognitionheathypoxia
Identifiers
PMID42496010
PMCPMC13463305
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