Evidence map›Paper›PMID 42495777›Full record

ArticleOncology reports2026

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling.

Jianwei Sun, Haifeng Liang, Yan Zhang, Ding Ding, Qian Xiang, Mengyang Zheng, Pengyue Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianwei SunDepartment of Ultrasound, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Haifeng LiangDepartment of Oncology, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Yan ZhangDepartment of Oncology, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Ding DingDepartment of Ultrasound, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Qian XiangDepartment of Endocrinology, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Mengyang ZhengDepartment of Ultrasound, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, Yunnan 661000, P.R. China.
Pengyue ZhangKey Laboratory of Acupuncture and Massage for Treatment of Encephalopathy, College of Acupuncture, Tuina and Rehabilitation, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphyllin II, a natural steroidal saponin extracted from

Indexed as

DiosgeninSaponinsThyroid NeoplasmsWnt Signaling PathwayAnimalsApoptosisbeta CateninCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMolecular Docking SimulationSteroidsbeta CateninDiosgeninpolyphyllin IISaponinsSteroidshistamine receptor H1polyphyllin IIthyroid cancerWnt/β‑catenin signaling pathway

Identifiers

PMID42495777
PMCPMC13443399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.