Evidence map›Paper›PMID 42495742›Full record

ArticleCirculation research2026

Metabolomic Profiles and Changes During the 20 Years Preceding Heart Failure.

Jiangtao Li, Shusi Ding, Zhao Yang, Mingdan Wang, Xuan Deng, Xueting Sun, Wenting Lu, Pingping Jia, Yan Liu, Yuhan Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiangtao Li *Beijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0009-0007-2209-1045
Shusi Ding *Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection (S.D., L.Z.), Capital Medical University, Beijing, China.ORCID 0000-0002-0360-9896
Zhao YangBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0002-5891-5815
Mingdan WangBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0009-0004-4845-0884
Xuan DengBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.
Xueting SunBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.
Wenting LuBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.
Pingping JiaBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0003-1107-5246
Yan LiuBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0003-2189-4712
Yuhan ZhangBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0002-2768-3900
Jun CaiBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0002-8928-9570
Lemin ZhengBeijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection (S.D., L.Z.), Capital Medical University, Beijing, China.ORCID 0000-0003-4473-6936
Yue QiBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0002-6709-7041
Jing LiuBeijing Anzhen Hospital (J. Li, Z.Y., M.W., X.D., X.S., W.L., P.J., Y.L., Y.Z., J.C., Y.Q., J. Liu), Capital Medical University, Beijing, China.ORCID 0000-0002-3311-0818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLongitudinal metabolomic studies can refine understanding of heart failure (HF) progression and enable precision prevention. This study aims to identify serum metabolites associated with HF risk via longitudinal metabolomic analysis, delineate their dynamic trajectories, and explore metabolite profiles in populations with different metabolic disorders.

methodsThis study analyzed longitudinal serum metabolomic data from 4774 serum samples from 1728 HF-free participants in the Chinese Multi-Provincial Cohort Study Metabolomics Project at 4 time points over a 20-year follow-up. Intensity models and Cox proportional-hazards models identified metabolites associated with HF risk. Latent variable mixed-effects models evaluated metabolite trajectories.

resultsOf the 784 detected metabolites, 23 were associated with HF risk at a false discovery rate-adjusted

conclusionsThis longitudinal metabolomic study identifies HF-associated metabolite profiles, characterizes their changes during the 20 years preceding clinical diagnosis, and reveals heterogeneity across individuals with different metabolic disorders, thereby informing future biomarker and intervention research.

Indexed as

Heart FailureMetabolomeMetabolomicsAgedBiomarkersChinaDisease ProgressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsTime FactorsBiomarkersbiomarkersheart failurelongitudinal studiesmetabolic diseasesmetabolomics

Identifiers

PMID42495742
PMCPMC13521254

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