ReviewFrontiers in immunology2026
Cell surface RNAs define a new interface for immune recognition.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Cell surface glycoRNAs have recently emerged as an unexpected class of RNA-glycan conjugates. Their discovery challenges the long-standing view that RNA is confined to intracellular compartments. These small noncoding RNAs, modified with N- or O-linked glycans and displayed on the outer leaflet of the plasma membrane, create a unique molecular interface recognizable by both glycan-binding and nucleic acid-sensing immune receptors. Recent studies suggest that glycoRNAs engage multiple immune receptor families, including P-selectin, Siglecs, Toll-like receptors (TLRs), and lectins, to influence neutrophil trafficking, immune activation, and tolerance. For instance, interactions between P-selectin and glycoRNAs have been implicated in neutrophil recruitment. In this Mini-Review, we summarize current knowledge of the molecular features of glycoRNAs and their emerging interfaces with immune receptors and discuss how glycoRNAs may represent a new layer of immune regulation at the cell surface.
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