ArticleFrontiers in immunology2026
Unique expression pattern of circulating exosomal miRNA correlates with CNS pathology.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: To investigate the total circulating exosome transcriptome in animal models of two different CNS pathologic conditions, autoimmune demyelination and traumatic brain injury (TBI). Methods: Next generation sequencing (NGS) was used to define the global RNA profile of blood exosomes in the MOG-induced EAE model of autoimmune demyelination and TBI mice model. We analyzed 5 million reads per sample, including a detailed analysis of microRNAs (miRNAs) differentially expressed in EAE versus control mice and versus TBI model. Results: Exosomal RNA NGS revealed 10 different classes of transcripts including miRNA. MiRNA numbers from EAE and TBI mice showed trend to be lower versus control mice. The differentially expressed miRNAs were found in all three sequential EAE time points: early stage post mice immunization (EAEp), peak of disease (EAEa) and recovery (EAEl). The differential expression pattern of miRNA in EAE versus TBI correlated with their involvement in activation or inhibition of immune response. In the early stage of EAE miRNA-335-5p and miRNA-411-5p were upregulated versus TBI. At the peak of disease six miRNAs were most upregulated, miRNA-27a-3p, miRNA-141-3p, miRNA27b-3p, miRNA-195a-5p, miRNA21a-5p and miRNA-99a-5p. The six most upregulated miRNA at the recovery time point of EAE, miRNA-27b-3p, miRNA 141-3p, miRNA 27a-3p, miRNA-127-3p, miRNA-429-3p and let-7b-5p were associated with inhibition of immune response and enhancement of immunoregulation. Interestingly, it was found that similar pattern of downregulated miRNAs versus TBI were present at all three of EAE time points. Bioinformatic analysis of protein genes targeted by the most differentially expressed miRNAs revealed a numbers of proteins involved in neuroinflammation both in EAE and TBI models. In the early phase of EAE, three protein transcripts, Hdac9, Syt7 and NT5c2 serve as an epigenetic switch controlling T cell fate and cytokine production. In recovery of EAE RoRb, a member of ROR nuclear receptor family involved in Th17 cell differentiation was inhibited. Discussion: These data indicate that different type of CNS pathology, autoimmune demyelination versus TBI is associated with different pattern of miRNA expression in circulating exosomes which may suggest their differential role in these two CNS pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.