Evidence map›Paper›PMID 42495603›Full record

ArticleFrontiers in immunology2026

The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells.

Lisa Isdraele Romano, Ilenia Aversa, Antonio Abatino, Costanza Maria Cristiani, Giulio Cesare Antico, Debora Gentile, Caterina Giordano, Emilio Straface, Michael Marrano, Elvira Angotti and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lisa Isdraele Romano *Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Ilenia Aversa *Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Antonio AbatinoDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Costanza Maria CristianiNeurosciences Research Centre, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Giulio Cesare AnticoLaboratory of Clinical Biochemistry, AOU "Renato Dulbecco" Hospital, Catanzaro, Italy.
Debora GentileDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Caterina GiordanoDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Emilio StrafaceDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Michael MarranoDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Elvira AngottiLaboratory of Clinical Biochemistry, AOU "Renato Dulbecco" Hospital, Catanzaro, Italy.
Camillo PalmieriDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Raffaella GalloDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Giuseppe FiumeDepartment of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin D is a pleiotropic steroid hormone with immunomodulatory properties. The role of the active metabolite, 1α,25-dihydroxyvitamin D Methods: Peripheral blood mononuclear cells (PBMCs) from healthy donors were cultured for five days in presence or absence of 1,25(OH) Results: 1,25(OH) Conclusions: These findings support an immunomodulatory effect of 1,25(OH)

Indexed as

CalcitriolCD8-Positive T-LymphocytesLymphocyte ActivationT-LymphocytesVitamin DCells, CulturedCTLA-4 AntigenHumansInterferon-gammaProgrammed Cell Death 1 ReceptorSignal TransductionCalcitriolCTLA-4 AntigenInterferon-gammaPDCD1 protein, humanProgrammed Cell Death 1 ReceptorVitamin D1,25(OH)2 vitamin DCTLA-4effector T cell activityimmune checkpoint regulationPD-1TIGITTIM3

Identifiers

PMID42495603
PMCPMC13391584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.