ArticleFrontiers in network physiology2026
Empirically constrained order parameter dynamics in cardiovascular criticality: a synergetic Langevin framework for arrhythmic transitions with cross-cohort parameter estimation and Kramers escape-time validation.
Article in Frontiers in network physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This companion empirical study established fundamental heterogeneity in pre-arrhythmic dynamical pathways across nine PhysioNet cohorts (N > 1,500 records): 93%-98% of events do not follow the canonical suppress-to-late-rise trajectory, Phase V (scaling manifold collapse, R Methods: A coupled Langevin system, grounded in Haken's synergetic order-parameter formalism, is reduced to dψ/dt = A (R Results: Rc = 0.991, a Conclusion: This study provides the first formal dynamical framework for the ECSoC empirical markers, deriving the pitchfork bifurcation structure of cardiovascular criticality from the first principles approach and validating it against cross-cohort data and stochastic simulations. The model is structurally validated across analytical, simulation, and empirical domains, with quantitative constraints in the large-noise regime delineating the boundary conditions for Kramers-based approximations. Six falsifiable predictions (P1-P6) define the roadmap for prospective quantitative validation.
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