Evidence map›Paper›PMID 42495577›Full record

ArticleJournal of the Endocrine Society2026

Distinguishing central precocious puberty from nonprogressive breast development: adiposity and DXA body composition.

Daniela Fava, Amanda Casirati, Maria Grazia Calevo, Alessia Angelelli, Alessia Pepe, Nadia Gabriella Maiorano, Lucia Acquarone, Chiara Santucci, Claudia Caridi, Valentina Tosto and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Daniela FavaPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-0128-6501
Amanda CasiratiPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-6005-5068
Maria Grazia CalevoEpidemiology and Biostatistics Unit, Scientific Directorate, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-6246-9299
Alessia AngelelliPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.
Alessia PepeDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Nadia Gabriella MaioranoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Lucia AcquaroneDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Chiara SantucciDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Claudia CaridiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Valentina TostoObstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0001-6228-3390
Marta PanciroliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Caterina TedescoPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.
Flavia NapoliPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0003-3567-6118
Anna Elsa Maria AllegriPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.
Giuseppa PattiPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.
Alessandro NaimDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa 16132, Italy.
Roberto GastaldiPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-2157-1158
Mohamad MaghniePediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-7183-5238
Natascia Di IorgiPediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa 16147, Italy.ORCID https://orcid.org/0000-0002-4492-4585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Distinguishing central precocious or early puberty (CPP/EP) from nonprogressive premature breast development (npPBD) is challenging, particularly in the context of increasing childhood adiposity, which may affect growth and skeletal maturation independently of hypothalamic-pituitary-ovarian (HPO) axis activation. Methods: We retrospectively evaluated 100 girls (69 CPP/EP, 31 npPBD) and 16 age-matched prepubertal girls with obesity as controls. Assessments included auxology, bone age, hormonal and metabolic profiles, pelvic ultrasound, DXA-derived body composition, and lifestyle factors. Results: Anthropometric parameters and bone age were similar between CPP/EP and npPBD, whereas LH, FSH, estradiol, and IGF-1 SDS (all Conclusion: Excess adiposity reduces the diagnostic specificity of auxological and skeletal maturation parameters in girls with early breast development. Biochemical assessment remains central, with IGF-1 SDS providing additional supportive information.

Indexed as

adipositybody compositiondual-energy X-ray absorptiometryprecocious puberty

Identifiers

PMID42495577
PMCPMC13392474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.