Evidence map›Paper›PMID 42495544›Full record

ArticleiScience2026

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease.

Maximilian G Griesbaum, Thomas Vogl, Marijn C Visschedijk, Eleonora A M Festen, Gerard Dijkstra, Adina Weinberger, Eran Segal, Rinse K Weersma, Arno R Bourgonje

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maximilian G GriesbaumDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thomas VoglCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Marijn C VisschedijkDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Eleonora A M FestenDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gerard DijkstraDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Adina WeinbergerDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Eran SegalDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Rinse K WeersmaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Arno R BourgonjeDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatigue is common and debilitating in inflammatory bowel disease (IBD), but its etiology remains unclear. Phage-display immunoprecipitation sequencing (PhIP-Seq) was used to profile systemic antibodies against 344,000 rationally selected peptide antigens in 327 patients with IBD, assessing associations with fatigue severity across quartiles and in a remission sub-cohort. No individual antibody remained significant after multiple testing correction. However, aggregation-based analyses identified recurring differences involving Epstein-Barr virus (EBV), influenza virus, and

Indexed as

antibody responsesbiomarkersEpstein-Barr virusfatiguehumoral immunityinflammatory bowel diseaseinfluenzaPhIP-SeqStaphylococcus

Identifiers

PMID42495544
PMCPMC13393791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.